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KMID : 1003219990050010219
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Journal of Korean Oriental Chronic Disease
1999 Volume.5 No. 1 p.219 ~ p.233
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Underlying mechanism of antioxidant action of Bombycis Corpus in hyperthyroidism
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손현주/Son, Hyun Ju
박종혁/윤철호/정지천/강정준/서종은/신억섭/Park, Jong Hyuck/Yoon, Cheol Ho/Jeong, Ji Cheon/Kang, Jeong Jun/Seo, Jong Eun/Shin, Uk Seob
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Abstract
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This study was carried out to examine if Bombycis Corpus (BOM) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats.
In vivo, Triiodothyronine(T3) and thyroxine(T4) were increased in thyroxine treated group. However, they were decreased in BOM extract´s pre-applied group. Lipid peroxidation was increased in thyroxine treated group. However, it was decreased in BOM extract´s pre-applied group. Xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in BOM extract´s pre-applied group. Glutathione level and activities of glutathione peroxidase, glutathione S-transferase and glutathione reductase were decreased in thyroxine treated group. However, they were increased in BOM extract´s pre-applied group.
These results suggest that BOM, in thyroxine-induced hyperthyroid rats, has an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities and thereby prevents lipid peroxidation.
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